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70 Multiple choice questions

  1. MPTP (Methyl Phenyl Tetrahydropyridine)

    MPP+
  2. Muscarinic (M)
  3. - Blocking D1 receptors
  4. 1. Tricyclic ring system
    2. Electron withdrawing group at "X" (position 2 carbon)
    3. Sulphur at position 5 has receptor binding function
    4. 3 carbon side chain between N10 and N of amino acid.
    (4 carbon side chain= antitussive, and 2 carbon side chain= Antihistamine)
  5. Induce
    Decrease
  6. Clozapine
  7. Aryl hydroxylation
    Oxidative deamination
  8. Inverse agonist
  9. Have not responded to other antipsychotic medications
    (Note: it was approved by FDA in 1989 with BBW requiring regular WBC count)
  10. Partial agonists
  11. Long acting
  12. - Phenothiazines
    - Thioxanthenes
    - Butyrophenones
  13. Dibenzoxepinopyrrole
  14. Piperazines > Piperidines > Dialkylamino
  15. Long (1/month IM injection)
  16. 1. Aryl hydroxylation
    2. N-dealkylation
  17. True
  18. Sedative
    EPS
  19. Less
  20. Assits activity
  21. Increase potency
  22. 1. Aryl hydroxylation
    2. N-dealkylation
    3. Oxidation (of S at position 5)
  23. - Loss if interest
    - Catatonia
    - Immobility
  24. Antitussive
  25. Butyrophenones
    5-HT2 antagonists
  26. Blocking (antagonism) of D2 receptors in the brain
  27. piperidine analog
  28. the Z isomer (because it is able to superimpose of dpoamine where as the E isomer can not)
  29. Eugene Bleuler
  30. More
  31. Essential for activity
  32. dialkylamino = piperidines > piperazines
  33. Lack of feelings or behaviors that are usually present
  34. Aripiprazole
    Asenapine
  35. Thiothixene
  36. - Antagonism in the CTZ in the brainstem
  37. Chlorpromazine
  38. 1. N-dealkylation and S-oxidation --> S-oxidation
    2. Aldehyde reductase --> S-methylation
  39. - Benzazepines
    - Benzisoxazole and Benzisothiazoles
    - Other/ Miscellaneous
  40. True
  41. dialkylamino = piperidines > piperazines
  42. Decanoate ester
  43. True
  44. Dehydroaripiprazole
    Dehydration
  45. Dopamine
    Glutamine
  46. 1. Substitution at position 1
    2. Substitution at position 4
    3. Branching at the beta carbon of the side chain by phenyl or polar group
  47. 1/month IM injection
  48. True
  49. Schizophrenia results from increased dopaminergic neurotransmission
  50. CF3 > SO2CF3 > SCF3 > SOCH3 > SCH3 > Cl > CH3 > H
  51. Essential for superimposing DA at the D2 receptor.
  52. Enhances activity
  53. Agranulocytosis which caused death in some patients
  54. D2
    5-HT2
  55. 1. Reduction --> Oxidative deamination
    2. Oxidative deamination --> Reduction
  56. Feelings or behaviors that are not usually present
  57. Piperazines > dialkylamino > piperidines
  58. Disorganization and cognitive impairment
  59. Antihistamine
  60. Antihelminthics
  61. Non-sedating
  62. - Oxidation of the sulphur
  63. Depression
  64. Essential for activity
  65. Superimpose on dopamine
  66. -CF3
  67. Dopamine antagonists at D2 receptors and may be at D3 or D4.
    Less frequent side effects
  68. Fluphenazine
  69. Ring
    (Bio-esters?)
  70. - Hallucinations
    - Delusions
    - Disturbances in thought