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41 Matching questions

  1. At >80% occupancy of D2 receptors by typical antipsychotics ____ can occur.
  2. Aripirazole decreases DA activity when...
  3. Lithium side effects...
  4. Side effects of combines H1 and 5-HT receptors?
  5. Other side effects of antipsychotics...
  6. Which is the prototype for atypical antipsychotics?
  7. What is the prototype drug for typical antipsychotics?
  8. Lithium MOA...
  9. What should be done if a patient develops tardive dyskinesia?
  10. Atypical antipsychotics have a higher affinity for _____ receptors.
  11. Atypical antipsychotics are effective with much less effect on _____.
  12. Aripiprazole stimulates D2 receptors if ______.
  13. Haloperidol has a high risk of ____ (side effect).
  14. Treatment options for Bipolar Disorder...
  15. Side effects from blocking alpha- adrenergic receptors?
  16. The most important and unwanted side effect of antipsychotic drugs is...
  17. What are the two main groups of antipsychotic medications?
  18. All of the newer generation antipsychotics have this MOA...
  19. Atypical antipsychotics are ______ of the 5-HT2A receptor.
  20. Clozapine is typically used now for ______ schizophrenia.
  21. Which is most widely used typical antipsychotic?
  22. Main side effects predicted by H1 receptor...
  23. Haloperidol is an ______ of D2 receptors.
  24. Aripiprazole is a ______ at D2 receptors.
  25. What is the serotonin hypothesis of schizophrenia?
  26. Most typical antipsychotics have a higher affinity for _____ receptors.
  27. What is the dopamine hypothesis of schizophrenia?
  28. Typical antipsychotics must occupy ____ of D2 receptors in the striatum.
  29. Effects of hyperprolactinemia?
  30. All of the older generation antipsychotics have this MOA...
  31. The "therapeutic" window for typical antipsychotics is ____ occupancy of D2 receptors.
  32. Atypical antipsychotics are effective at _____ occupancy of receptors.
  33. Most antipsychotics have an ______ effect.
  34. Side effects from blocking muscarinic receptors?
  35. What are signs/symptoms of neuroleptic malignant syndrome
  36. Side effects from blocking dopamine receptors?
  37. Lithium inhibits these enzymes...
  38. T/F: Most antipsychotics have no active metabolites.
  39. Side effects of antipsychotics come from binding....
  40. T/F: With the exception of aripiprazole, all antipsychotics have D2 blockade properties.
  41. Aripiprazole reduces ______ levels. (Hormone)
  1. a Weight gain
  2. b 65-80%
  3. c Refractory
  4. d Extra pyramidal symptoms
  5. e True
  6. f - Parkinson's syndrome
    - Akathisia
    - Dystonias
    - Hyperprolactinemia (except aripiprazole)
  7. g Tardive dyskinesia
  8. h - Dry mouth
    - Loss of accommodation
    - Difficulty urinating
    - Constipation
    - Toxic confusional state
  9. i 30-50%
  10. j Sedation
    Weight gain via appetite stimulation
  11. k - Inositol monophosphatase
    - Inositol polyphosphate 1-phosphatase
  12. l Partial agonist
  13. m Extra pyramidal side effects
  14. n Polyuria and compensatory polydipsia
    - Cardiovascular side effects at overdose levels
    - Benign thyroid enlargement, hypothyroidism
    - Weight gain
    - Fine postural hand tremor
  15. o Prolactin
  16. p - Breast enlargement
    - Galactorrhea
    - Amenorrhea and osteoporosis in women
    - Sexual dysfunction and infertility in men
  17. q DA activity is high
  18. r - Lithium
    - Anticonvulsants (Valproate, Carbamazepine)
    - Antipsychotics (Aripiprazole, Olanzapine, Ziprasidone)
  19. s Synaptic DA is limited
  20. t Dopamine receptors
  21. u >60%
  22. v D2
  23. w 1. First generation (older)
    2. Second generation (newer)
  24. x False; They typically have one or more active metabolites
  25. y Many atypical antipsychotics are potent 5-HT2C receptor antagonists/inverse agonists.
    - 5HT2A (5HT2C) activity activity modulates the release of several neurotransmitters
  26. z Blocking dopamine correlates with time course of behavioral effects
  27. aa Antagonist
  28. ab Clozapine
  29. ac - Agranulocytosis
    - Retinal deposits
    - Deposits in the cornea and lens
    - Seizures
    - QT prolongation
  30. ad - Orthostatic hypotension
    - Impotence
    - Failure to ejaculate
  31. ae Inhibits the rate limiting enzyme in inositol recycling, and this depletes PIP2 and second messangers
  32. af Severe case of Parkinsonism
    - Extreme muscle rigidity
    - Very high fever
    - Autonomic instability
    -Elevated muscle type creatine kinase levels
  33. ag 5-HT2
  34. ah Chlorpromazine
  35. ai Haloperidol
  36. aj Antiemetic
  37. ak - Alpha adrenoreceptors
    - Muscarinic receptors
    - H1 histamine reseptors
  38. al Switch therapy to quetiapine or clozapine
  39. am D2 and 5HT2A receptor blockers
  40. an Inverse agonists
  41. ao D2 blockers